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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 34 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-FCGR2B/CD32b (Tyr292) Rabbit Polyclonal Antibody detects endogenous levels of FCGR2B/CD32b protein only when phosphorylated at Tyr292. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
FCGR2B also known as Fc gamma RIIb, CD32b is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. CD32 plays a crucial role in the immune response by mediating the clearance of immune complexes through macrophages. This function is vital for maintaining homeostasis and preventing autoimmune reactions, as the binding of IgG to CD32 delivers inhibitory signals to B cells, thereby regulating antibody production. CD32 exists in several isoforms generated by alternative splicing of three distinct genes (A, B, and C), which are designated FcgRIIA, FcgRIIB1, FcgRIIB3, and FcgRIIC. These isoforms are expressed on various immune cells, including monocytes, placental trophoblasts, endothelial cells, and B lymphocytes, with specific isoforms found on neutrophils, highlighting CD32′s diverse roles in immune regulation and response. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells treated with PMA, using Phospho-FCGR2B/CD32b (Tyr292) Rabbit Polyclonal Antibody (EAB14907) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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