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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 38 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | AHSA1 Rabbit Polyclonal Antibody detects endogenous levels of AHSA1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
AHSA1 also designated AHA1 is a cytosolic protein and may transiently interact with the endoplasmic reticulum. AHSA1 plays a pivotal role in regulating heat shock protein 90 (HSP 90) complex, which is essential for protein folding and stabilization under stress conditions. Specifically, AHSA1 enhances HSP 90 ATPase activity, facilitating function in protein maturation and degradation pathways. Such regulation influences "ATP lid" conformational state and promotes N-terminal dimerization, crucial for HSP 90′s activity. AHSA1 predominantly resides in cytosol but can transiently associate with endoplasmic reticulum, impacting protein trafficking from endoplasmic reticulum to Golgi apparatus. Heat shock induces AHA-1 expression in various tissues, including brain, heart, skeletal muscle, and kidney, with lower levels in liver and placenta. |
| Product Image Gallery | |
 Western blot analysis of extracts on HT29, A549, K562 cells, using AHSA1 Rabbit Polyclonal Antibody (EAB11307) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue, using AHSA1 Rabbit Polyclonal Antibody (EAB11307) at 1:200 dilution.
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