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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, FC, ELISA | 42 | Human |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:100-500 FC=1:50-200 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Ring1A/RNF1 Mouse Monoclonal Antibody detects endogenous levels of Ring1A/RNF1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Ring1A also known as RNF1 is a member of the RING finger family. Ring1A plays a crucial role in the regulation of gene expression through involvement in chromatin remodeling and transcriptional repression, which is vital for maintaining cellular identity and preventing inappropriate gene activation. Specifically, Ring1A is part of the Polycomb group (PcG) proteins that form multimeric complexes essential for the repression of developmental genes, thereby influencing cell fate decisions during embryogenesis. A RING finger motif in Ring1A allows interaction with other regulatory proteins, facilitating function in chromatin modification. Ring1A′s ability to repress the expression of proto-oncogenes such as c-Jun and c-fos underscores importance in cellular growth regulation and oncogenesis. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HEK293, Jurkat cells, using Ring1A/RNF1 Mouse Monoclonal Antibody (EAB22719) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human rectum cancer tissue, using Ring1A/RNF1 Mouse Monoclonal Antibody (EAB22719) at 1:200 dilution.
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