| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 41 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PKA C-beta Rabbit Polyclonal Antibody detects endogenous levels of PKA C-beta protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PKA C-beta also known as PKACB, PKA C-β, PRKACB is a member of the serine/threonine protein kinase family. PKA C-beta is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. As part of the PKA holoenzyme regulated by regulatory subunits and A-kinase anchoring proteins (AKAPs), PKA C-beta contributes to spatially confined signaling within pathways such as CREB-mediated gene expression, MAPK crosstalk, and modulation of insulin and calcium-dependent processes. Altered PKA signaling has been linked to dysregulated cell growth and differentiation, neuronal function, and endocrine/metabolic phenotypes, making PKA C-beta a useful target for dissecting compartmentalized cAMP signaling. |
| Product Image Gallery | |
 Western blot analysis of extracts on COLO205, Jurkat cells, using PKA C-beta Rabbit Polyclonal Antibody (EAB14921) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 41 kDa; Observed band size: 53 kDa  Immunohistochemistry of paraffin-embedded Human tonsil tissue, using PKA C-beta Rabbit Polyclonal Antibody (EAB14921) at 1:200 dilution.
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