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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 20 | Human, Mouse, Rat, Monkey |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-CRYAB (Ser45) Rabbit Polyclonal Antibody detects endogenous levels of CRYAB protein only when phosphorylated at Ser45. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CRYAB also known as αB-crystallin, Crystallin alpha B is a member of the small heat shock protein family. CRYAB plays a crucial role in cellular stress response by acting as a molecular chaperone, preventing the aggregation of denatured proteins and maintaining cellular protein homeostasis. This function is particularly important in tissues that are subject to high levels of stress, such as the heart and skeletal muscle, where elevated expression of CRYAB has been linked to various neurological diseases. Notably, a missense mutation in the CRYAB gene has been associated with Desmin-related myopathy, highlighting its significance in muscle integrity and function. The unique structure of CRYAB, which includes a conserved α-crystallin domain, allows CRYAB to interact with a variety of client proteins, thereby influencing their stability and activity. |
| Product Image Gallery | |
 Western blot analysis of extracts on COS7 cells treated with Anisomycin, using Phospho-CRYAB (Ser45) Rabbit Polyclonal Antibody (EAB14975) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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