| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 99 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-Lipin 1 (Ser889) Rabbit Polyclonal Antibody detects endogenous levels of Lipin 1 protein only when phosphorylated at Ser889. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Lipin 1 also known as LPIN1 is a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Lipin 1 plays a pivotal role in lipid metabolism and energy homeostasis, functioning as a phosphatidate phosphatase that converts phosphatidate to diacylglycerol, a key step in triglyceride synthesis. This enzymatic activity is crucial for the regulation of lipid storage and mobilization, impacting overall metabolic health. Dysregulation of Lipin 1 can lead to metabolic disorders, including insulin resistance and lipodystrophy, highlighting Lipin 1′s importance in maintaining normal adipose tissue function. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2 cells, using Phospho-Lipin 1 (Ser889) Rabbit Polyclonal Antibody (EAB11331) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
