| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, FC, ELISA | 110 | Human, Mouse, Monkey |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | ATP2A1/SERCA1 Mouse Monoclonal Antibody detects endogenous levels of ATP2A1/SERCA1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
ATP2A1 also known as SERCA1 is a member of the sarcoplasmic or endoplasmic reticulum calcium ATPase family. ATP2A1 plays a crucial role in muscle physiology by mediating the uptake of calcium ions into the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. Proper functioning of ATP2A1 is vital for maintaining low cytoplasmic calcium concentrations, thereby preventing excessive muscle contraction and ensuring efficient muscle relaxation. This regulation is particularly important in type II (fast) skeletal muscle, where ATP2A1 is exclusively expressed, allowing for rapid and powerful muscle contractions. ATP2A1′s activity is influenced by various post-translational modifications, which can affect function and stability, highlighting the importance of understanding these modifications in the context of muscle health and disease. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Jurkat, COS7, C2C12 cells, using ATP2A1/SERCA1 Mouse Monoclonal Antibody (EAB22731) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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