| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 33 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-MyD88 (Tyr257) Rabbit Polyclonal Antibody detects endogenous levels of MyD88 protein only when phosphorylated at Tyr257. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MyD88 is a cytosolic adapter protein that plays a crucial role in the innate immune response, acting as an adaptor protein that facilitates the signaling cascade initiated by the interleukin-1 receptor, which is vital for the activation of the NFκB pathway. This pathway is essential for the transcription of pro-inflammatory cytokines and other immune response genes, highlighting MyD88′s importance in mediating inflammatory responses and maintaining immune homeostasis. MyD88′s structure includes a distinctive N-terminal death domain, which is critical for interaction with interleukin-1 receptor-associated kinase (IRAK), and a Toll/IL-1R homology domain that enables association with the IL-1 receptor complex. |
| Product Image Gallery | |
 Western blot analysis of extracts on A431 cells treated with Serum-free, using Phospho-MyD88 (Tyr257) Rabbit Polyclonal Antibody (EAB11679) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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