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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC | 116 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | KL/Klotho Rabbit Polyclonal Antibody detects endogenous levels of KL/Klotho protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Klotho also known as KL, HFTC3 is a type-I membrane protein that is related to beta-glucosidases. The amino terminal extracellular domain has two internal repeats, known as KL-1 and KL-2, which have partial sequence homology to beta-glucosidases and lactase glycosylceramidase, suggesting a role for Klotho in sphingolipid metabolism. The human klotho gene maps to chromosome 13q12 and encodes a 1012 amino acid protein that is abundant in the kidney and brain. Chronic renal failure (CRF) patients express lower levels of klotho mRNA and protein in the kidneys. |
| Product Image Gallery | |
 Western blot analysis of extracts on DU145, Mouse kidney, Mouse brain cells, using Phospho-Mnk1 (Thr255) Rabbit Polyclonal Antibody (EAB22438) at 1:2000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 116 kDa; Observed band size: 65,120 kDa  Immunohistochemistry of paraffin-embedded Human lung cancer tissue, using Phospho-Mnk1 (Thr255) Rabbit Polyclonal Antibody (EAB22438) at 1:200 dilution.
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