| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 49 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | FNTB Rabbit Polyclonal Antibody detects endogenous levels of FNTB protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
FNTB also known as FTβ is a key enzyme in the mevalonate-dependent prenylation pathway that covalently attaches a farnesyl isoprenoid to C-terminal CaaX motifs. FNTB plays a crucial role in post-translational modification of proteins through farnesylation, a process essential for proper localization and function of several key proteins, including nuclear lamins and oncogene p21Ras. This modification is vital for membrane association of these proteins, influencing their activity and interactions within the cell. The farnesyl transferase enzyme, consisting of a heterodimer of α and β subunits, facilitates attachment of farnesyl residues to specific cysteine residues in target proteins, thereby regulating various cellular processes such as signal transduction and cell division. |
| Product Image Gallery | |
 Western blot analysis of extracts on Raw246.7, NIH/3T3 cells, using FNTB Rabbit Polyclonal Antibody (EAB12003) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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