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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, FC, ELISA | 136 | Human |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 FC=1:50-200 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | ADAR1 Mouse Monoclonal Antibody detects endogenous levels of ADAR1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
ADAR1 plays a crucial role in RNA editing by converting adenosine to inosine in double-stranded RNA, essential for gene expression regulation and cellular homeostasis maintenance. This editing process is particularly important in immune response, as ADAR1 can modulate viral RNA recognition, influencing host response to infections. ADAR1 is expressed from an interferon-response promoter and features a Z-DNA/Z-RNA binding domain at N-terminus, vital for RNA editing function. ADAR1′s ability to bind short interfering RNA (siRNA) suggests potential limitation of siRNA-mediated gene silencing in mammalian cells, making ADAR1 a critical player in RNA biology and therapeutic applications. |
| Product Image Gallery | |
 Western blot analysis of extracts on Romas, K562 cells, using ADAR1 Mouse Monoclonal Antibody (EAB22311) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Predicted band size: 136 kDa; Observed band size: 110 kDa |
