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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 155 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-Src-3 (Ser857) Rabbit Polyclonal Antibody detects endogenous levels of Src-3 protein only when phosphorylated at Ser857. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Src-3 also known as RAC3, ACTR, AIB-1, p/CIP, NCoA-3, plays a crucial role as a transcriptional coactivator in the steroid receptor family, facilitating the transcriptional activation of hormone-responsive genes. NCoA-3 is particularly significant due to its involvement in the regulation of gene expression linked to various physiological processes, including cell growth and differentiation. Notably, NCoA-3 is often overexpressed in estrogen receptor-positive ovarian and breast cancers, highlighting its importance in cancer biology and potential as a therapeutic target. The interaction of NCoA-3 with other proteins, such as p300/CBP, underscores its role in enhancing transcriptional activity, making NCoA-3 a vital component in the signaling pathways that govern cellular responses to hormones. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7 cells treaded with LPS, using Phospho-Src-3 (Ser857) Rabbit Polyclonal Antibody (EAB13316) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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