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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IP, IHC-P, IF/ICC, ELISA | 123 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:2000-10000 IP=1:100-500 IHC-P=1:200-1000 IF/ICC=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Exportin-1/CRM1 Mouse Monoclonal Antibody detects endogenous levels of Exportin-1/CRM1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CRM1 also known as Exportin-1, XPO1 is a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. CRM1 plays a crucial role in nuclear export of proteins and RNA, particularly those containing a nuclear export signal (NES). CRM1′s function is vital for maintaining cellular homeostasis and regulating gene expression, as CRM1 facilitates transport of essential molecules out of the nucleus, thereby influencing various cellular processes such as signal transduction and stress responses. CRM1′s interaction with specific leucine-rich proteins underscores its importance in selective export mechanism, which is essential for proper cellular function. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HepG2, Raw264.7, NIH/3T3 cells, using Exportin-1/CRM1 Mouse Monoclonal Antibody (EAB22173) at 1:5000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Predicted band size: 123 kDa; Observed band size: 100-110 kDa |
