www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IF/ICC | 127 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IF/ICC=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-LATS1 (Thr1079) Rabbit Monoclonal Antibody detects endogenous levels of LATS1 only when phosphorylated at Thr1079. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LATS1 is a homolog of the Drosophila tumor suppressor protein lats, functions as a serine/threonine kinase that plays a crucial role in regulating cell growth and cell cycle. LATS1′s ability to inhibit Cdc2 activity during early mitosis is vital for maintaining proper cell division and preventing uncontrolled proliferation, which is a hallmark of cancer. Studies show that LATS1-deficient mice exhibit heightened sensitivity to carcinogenic treatments and develop various tumors, including soft-tissue sarcomas and ovarian stromal cell tumors, highlighting LATS1′s essential role in tumor suppression and consequences of dysregulation in mammalian systems. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells treated with Calyculin A, using Phospho-LATS1 (Thr1079) Rabbit Monoclonal Antibody (EAB22297) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
Predicted band size: 127 kDa; Observed band size: 130 kDa |
