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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 50 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | N-Myc Rabbit Polyclonal Antibody detects endogenous levels of N-Myc protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
N-Myc also known as MYCN is a member of the Myc family of oncogenes. N-Myc plays a crucial role in cell proliferation, differentiation, and apoptosis, making N-Myc a significant factor in cancer biology. N-Myc amplification is particularly relevant in neuroblastomas, where N-Myc has been shown to correlate with disease progression, highlighting N-Myc′s potential as a biomarker for diagnosis and prognosis. Structurally, N-Myc is a nuclear phosphoprotein that undergoes rapid degradation, with a half-life of approximately 30 minutes in vivo, which is essential for regulating N-Myc activity and preventing uncontrolled cell growth. N-Myc′s ability to bind DNA in a sequence-specific manner, following dimerization with the Max protein, underscores N-Myc′s importance in transcriptional regulation and oncogenic processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on CACO2 cells, using N-Myc Rabbit Polyclonal Antibody (EAB11812) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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