www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 30 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | HES1 Rabbit Polyclonal Antibody detects endogenous levels of HES1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
HES1 is a member of the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 plays a crucial role in the regulation of myogenesis and neurogenesis, functioning as a transcriptional repressor within the Notch signaling pathway. This pathway is essential for proper cell differentiation and development, particularly during embryogenesis, where HES1 helps control segmentation and neural development. HES1, along with its family members, forms a complex with TLE proteins, which are the mammalian homologs of the Drosophila groucho proteins. This interaction is mediated by the carboxy-terminal WRPW motif of the HES proteins, allowing the HES/TLE complex to bind directly to DNA and regulate gene expression without interfering with activator proteins. |
| Product Image Gallery | |
 Western blot analysis of extracts on HuvEc cells, using HES1 Rabbit Polyclonal Antibody (EAB13086) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
