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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 77 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | STIM1 Rabbit Polyclonal Antibody detects endogenous levels of STIM1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
STIM1(Stromal interaction molecule 1) also konw as TAM1 is a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). STIM1 plays a significant role in mediating calcium influx, particularly following the depletion of intracellular calcium stores. Located primarily in the endoplasmic reticulum, STIM1 functions as a calcium sensor due to its EF-hand domain, which undergoes substantial conformational changes in response to fluctuating calcium levels. When intracellular calcium levels drop, STIM1 translocates to the plasma membrane, where STIM1 activates the calcium release-activated calcium (CRAC) channel subunit, TMEM142A/Orai1, facilitating the influx of calcium ions essential for various cellular processes, including secretion and transcription. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, MCF7 cells, using STIM1 Rabbit Polyclonal Antibody (EAB12166) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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