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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IF/ICC, ELISA | 53 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IF/ICC=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | GSDMD Mouse Monoclonal Antibody detects endogenous levels of GSDMD protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
GSDMD also known as GSDMDC1, Gasdermin D is a member of the gasdermin family. GSDMD consisting of 484 amino acids, plays a crucial role in regulating cell death and inflammation, which is vital for maintaining tissue homeostasis and responding to cellular stress. GSDMD function is particularly important in various diseases, including cancer, where dysregulation of cell death pathways can lead to tumor progression and resistance to therapy. GSDMD gene is located on human chromosome 8, a region implicated in several genetic disorders and malignancies. Notably, alterations in chromosome 8, such as translocations and amplifications, are often associated with poor prognoses in leukemias and lymphomas. |
| Product Image Gallery | |
 Western blot analysis of extracts on U2OS, THP-1,Mouse brain cells, using GSDMD Mouse Monoclonal Antibody (EAB12097) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Predicted band size: 53 kDa; Observed band size: 31,53 kDa |
