www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IF/ICC, FC, ELISA | 57 | Human, Mouse, Rat, Monkey |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IF/ICC=1:100-500 FC=1:50-200 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TCP1β/CCT2 Mouse Monoclonal Antibody detects endogenous levels of TCP1β/CCT2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TCP1β also known as TCP1 beta, CCT2 is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for proper folding of cytosolic proteins, particularly actins and tubulins. Located in the eukaryotic cytosol, CCT complex comprises eight distinct subunits, each encoded by different genes, and maintains cellular function and integrity. TCP1β′s role in protein folding is particularly important, as misfolded proteins can lead to cellular dysfunction and various diseases. TCP1β was initially identified in mice, where studies linked this protein to tail-less and embryonic lethal phenotypes, and homologous sequences appear in several other species, highlighting evolutionary significance. Studies of TCP1β in yeast demonstrate molecular chaperone activity for actin and tubulin, underscoring this protein′s critical role in cellular processes across different organisms. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, MCF7, Jurkat, A431, T47D cells, using TCP1β/CCT2 Mouse Monoclonal Antibody (EAB22631) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
|
