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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 69 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-c-Rel (Ser492)Rabbit Polyclonal Antibody detects endogenous levels of c-Rel only when phosphorylated at Ser492. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
c-Rel also known as Rel is a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. c-Rel plays a crucial role in transcriptional activation of immunoglobulin kappa light chain genes, thereby influencing B cell development and function. c-Rel is a vital component of the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) signaling pathway, which is essential for regulating immune responses, cell proliferation, and survival. Through binding to specific κB sites in promoter regions of target genes, Proper regulation of c-Rel is important because dysregulation can lead to various immune disorders and contribute to cancer development. In contrast to v-Rel, which lacks a functional C-terminal transactivation domain and disrupts normal NFκB signaling, c-Rel maintains a role as a transcriptional activator, highlighting significance in maintaining cellular homeostasis and immune function. |
