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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IF/ICC, ELISA | 39 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IF/ICC=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Caspase-12 Rabbit Monoclonal Antibody detects endogenous levels of Caspase-12 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Caspase-12 also known as CASP12 is a member of the Ced-3/caspase-1 family of cysteine proteases. Caspase-12 plays a crucial role in apoptotic process by mediating the cleavage of specific target proteins essential for cellular survival and homeostasis. Caspase-12 is primarily located in the endoplasmic reticulum, where caspase-12 is involved in initiating apoptosis in response to cellular stress and inflammation. This localization is significant because caspase-12 enables rapid activation of apoptotic pathways in response to endoplasmic reticulum stress, which can lead to cell death if unresolved. Aberrations in caspase-12 function have been implicated in various diseases, including neurodegenerative disorders and cancer, highlighting caspase-12′s importance as a potential therapeutic target. |
