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FCCP (CAS: 370-86-5)
Catalog #:EBC51061
  SKU-Pack Size Availability Size Price
EBC51061-1ML In Stock 1mL(10mM in DMSO) ¥490.00
EBC51061-5MG In Stock 5mg ¥390.00
EBC51061-10MG In Stock 10mg ¥590.00
EBC51061-50MG In Stock 50mg ¥1990.00
EBC51061-100MG In Stock 100mg ¥3290.00
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Product Information
Synonym(s) Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, Trifluoromethoxy carbonylcyanide phenylhydrazone
Chemical Name Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Application FCCP is a very potent oxidative phosphorylation uncoupler found in mitochondria
CAS Number 370-86-5
Purity ≥99.0%
Molecular Weight 254.17
Molecular Formula C₁₀H₅F₃N₄O
SMILES FC(F)(F)Oc1ccc(cc1)NN=C(/C#N)C#N
Target & IC50 hypoxia-induced HIF1 activation: IC50 = 510 nM
Solubility DMSO: 50 mg/mL (196.72 mM)
Ethanol: 50 mg/mL (196.72 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.9344 ml 19.6719 ml 39.3437 ml
5 mM 0.7869 ml 3.9344 ml 7.8687 ml
10 mM 0.3934 ml 1.9672 ml 3.9344 ml
50 mM 0.0787 ml 0.3934 ml 0.7869 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

FCCP is an oxidative phosphorylation uncoupler in mitochondria. FCCP is capable of depolarizing plasma and mitochondrial membranes. FCCP disrupts ATP synthesis by transporting protons across cell membranes. FCCP induces complete depolymerization of microtubules at 40 µM by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins. FCCP is also known as Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, and 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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