Protein Inhibitors - (-)-Blebbistatin (CAS: 856925-71-8)

(-)-Blebbistatin (CAS: 856925-71-8)

Catalog #：EBC51005

(-)-Blebbistatin (CAS: 856925-71-8)

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Product Information

Synonym(s)

(S)-(-)-Blebbistatin, (S)-(-)-Blebbistatin

Chemical Name

1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2.3-b]-7-methylquinolin-4-one

Application

-(−)-Blebbistatin is an inhibitor of myosin II

CAS Number

856925-71-8

Purity

≥99%

Molecular Weight

292.33

Molecular Formula

C₁₈H₁₆N₂O₂

SMILES

CC1=CC=C(N=C(N(C2=CC=CC=C2)CC3)[C@]3(O)C4=O)C4=C1

Target & IC50

myosin II ATPase activity: IC50 = 5 μM
ATPase: IC50 = 2 μM
smooth muscle myosin: IC50 = 80 μM

Solubility

DMSO: 29.2 mg/mL (100 mM）

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20° C

Research Use

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Description
(S)-(−)-Blebbistatin is a selective inhibitor of myosin II (MYH2). It also inhibits contraction of the cleavage furrow without disrupting of mitosis or the contractile ring assembly. (S)-(−)-Blebbistatin exhibits rapid and reversible blocking of cell blebbing, as well as disruption of directed cell migration and of cytokinesis in vertebrate cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol