Protein Inhibitors - KU-55933 (CAS: 587871-26-9)

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KU-55933 (CAS: 587871-26-9)

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Catalog #：EBC51008

Datasheet

KU-55933 (CAS: 587871-26-9)

SKU-Pack Size	Availability	Size	Price
EBC51008-1ML	In Stock	1mL(10mM in DMSO)	$103.50
EBC51008-5MG	In Stock	5mg	$103.50
EBC51008-25MG	In Stock	25mg	$268.50
EBC51008-50MG	In Stock	50mg	$403.50
EBC51008-100MG	In Stock	100mg	$523.50

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Product Information

Synonym(s)

ATM Kinase Inhibitor

Chemical Name

2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one

Application

ATM Kinase Inhibitor is a cell-permeable, potent, selective and ATP-competitive ATM inhibitor

CAS Number

587871-26-9

Purity

≥99.0%

Molecular Weight

395.49

Molecular Formula

C₂₁H₁₇NO₃S₂

SMILES

C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

Target & IC50

Atm: IC50 = 13 nM
mTOR: IC50 = 9.3 μM
PI3K: IC50 = 16.6 μM

Solubility

DMSO: 39.6 mg/mL (100 mM)
Ethanol: 19.8 mg/mL (50 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.5285 ml	12.6425 ml	25.2851 ml
5 mM	0.5057 ml	2.5285 ml	5.0570 ml
10 mM	0.2529 ml	1.2643 ml	2.5285 ml
50 mM	0.0506 ml	0.2529 ml	0.5057 ml

Shipping

Gel Pack

Storage

Store at -20° C

Research Use

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Description

ATM Kinase Inhibitor (KU 55933) is a cell-permeable, potent, selective and ATP-competitive inhibitor of ATM (Ataxia telangiectasia mutated), a serine/threonine protein kinase, that exhibits an IC50 of 13 nmol/L and a Ki of 2.2 nmol/L. ATM is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells and signals to cell cycle and DNA repair components by phosphorylating downstream targets such as p53, CHK2, NALP2 (NBS1), and BRCA1.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol