Protein Inhibitors - NSC632839 (CAS: 157654-67-6)

NSC632839 (CAS: 157654-67-6)

Catalog #：EBC51024

NSC632839 (CAS: 157654-67-6)

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Product Information

Synonym(s)

NSC 632839,NSC-632839

Chemical Name

3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride

Application

NSC 632839 is an inhibitor of ubiquitin isopeptidase activity

CAS Number

157654-67-6

Purity

≥99.0%

Molecular Weight

339.86

Molecular Formula

C₂₁H₂₂ClNO

SMILES

CC1=CC=C(C=C1)/C=C\2/C(=O)/C(=C/C3=CC=C(C=C3)C)/CNC2.Cl

Target & IC50

CEM: IC50 = 1.69 μM (human)
L1210: IC50 = 8.47 μM (mouse)
E1A cells: IC50 = 15.65 μM
E1A/C9CN cells: IC50 = 16.23 μM

Solubility

DMSO: 6.2 mg/mL

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
NSC 632839is an inhibitor of USP (ubiquitin isopeptidase) activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol