Protein Agonists, Antagonists and Activators - Batefenterol (CAS: 743461-65-6)

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Batefenterol (CAS: 743461-65-6)

Catalog #：EBC51037

Datasheet

Batefenterol (CAS: 743461-65-6)

SKU-Pack Size	Availability	Size	Price
EBC51037-1ML	In Stock	1mL(10mM in DMSO)	$403.50
EBC51037-1MG	In Stock	1mg	$88.50
EBC51037-5MG	In Stock	5mg	$223.50
EBC51037-10MG	In Stock	10mg	$343.50
EBC51037-25MG	In Stock	25mg	$478.50

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Product Information

Synonym(s)

GSK961081, TD-5959

Chemical Name

(R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

Application

Batefenterol is a muscarinic receptor antagonist and β2-adrenoceptor agonist

CAS Number

743461-65-6

Purity

≥98.0%

Molecular Weight

740.24

Molecular Formula

C₄₀H₄₂ClN₅O₇

SMILES

O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)=O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

Target & IC50

hβ2-adrenoceptor agonist: EC50 = 0.29 nM

Solubility

DMSO: 100 mg/mL (135.09 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.3509 ml	6.7545 ml	13.5091 ml
5 mM	0.2702 ml	1.3509 ml	2.7018 ml
10 mM	0.1351 ml	0.6755 ml	1.3509 ml
50 mM	0.0270 ml	0.1351 ml	0.2702 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

Batefenterol is a Muscarinic Antagonist and β2-Agonist possessing both muscarinic antagonist (MA) and β2-adrenoceptor agonist (BA) properties (MABA). GSK-961081 displayed high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). GSK-961081 behaved as a potent hβ2-adrenoceptor agonist (EC50 = 0.29 nM for stimulation of cAMP levels) with 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors, respectively.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol