Protein Inhibitors - Apremilast (CAS: 608141-41-9)

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Apremilast (CAS: 608141-41-9)

Catalog #：EBC51039

Apremilast (CAS: 608141-41-9)

SKU-Pack Size	Availability	Size	Price
EBC51037-1ML	In Stock	1mL(10mM in DMSO)	￥1190.00
EBC51039-2MG	In Stock	5mg	￥740.00
EBC51039-10MG	In Stock	10mg	￥1190.00
EBC51039-25MG	In Stock	25mg	￥1990.00
EBC51039-50MG	In Stock	50mg	￥2690.00

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Product Information

Synonym(s)

CC-10004, CC 10004, CC10004

Chemical Name

(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Application

Apremilast is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.

CAS Number

608141-41-9

Purity

≥99.0%

Molecular Weight

460.5

Molecular Formula

C22H24N2O7S

SMILES

C(=O)1C2=C(C(NC(C)=O)=CC=C2)C(=O)N1[C@H](C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O

Target & IC50

PDE4: IC50 = 74 nM
TNF-α: IC50 = 77 nM

Solubility

DMSO: 92 mg/mL (199.78 mM)（br） Ethanol: 3 mg/mL (6.51 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.1716 ml	10.8578 ml	21.7155 ml
5 mM	0.4343 ml	2.1716 ml	4.3431 ml
10 mM	0.2172 ml	1.0858 ml	2.1716 ml
50 mM	0.0434 ml	0.2172 ml	0.4343 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Apremilast is more potent For inhibition of PDE4 compared with cAMP or cGMP hydrolysing enzymes from other PDE families. Apremilast displays a broad pattern of anti-inflammatory activity in a variety of cell types, inhibits TNF-α, IL-12 and IL-23 product

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol

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