Protein Inhibitors - PD184352 (CAS: 212631-79-3)

PD184352 (CAS: 212631-79-3)

Catalog #：EBC51018

PD184352 (CAS: 212631-79-3)

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Product Information

Synonym(s)

CI-1040, CI 1040, CI1040, PD 184352, PD-184352

Chemical Name

2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

Application

PD184352 is a MEK inhibitor

CAS Number

212631-79-3

Purity

≥99.0%

Molecular Weight

478.66

Molecular Formula

C₁₇H₁₄ClF₂IN₂O₂

SMILES

O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2Cl)F)NOCC3CC3

Target & IC50

MEK-1: IC50 = 2 nM
Raf-1: IC50 = 12 nM
MEK1/2: IC50 = 16 nM

Solubility

DMSO: 47.9 mg/mL (100 mM)
Ethanol: 12 mg/mL (25 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
PD184352 is a MEK inhibitor (IC50 = 10-100 nM), a kinase upstream in the mitogen-activated protein kinase pathway (MAPK). Inhibition of MEK leads to a reduction of MAPK activation, suppressing colon tumor proliferation in mice with limited organism toxicity. PD 184,352 is an inhibitor of MEK-1 and MEK-2.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol