Protein Inhibitors - XAV939 (CAS: 284028-89-3)

XAV939 (CAS: 284028-89-3)

Catalog #：EBC51062

XAV939 (CAS: 284028-89-3)

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Product Information

Synonym(s)

Tankyrase inhibitor, XAV 939, XAV-939, NVP-XAV939

Chemical Name

2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one

Application

XAV939 is a potent inhibitor of beta-catenin, TNKS1, and TNKS2

CAS Number

284028-89-3

Purity

≥98.5%

Molecular Weight

312.31

Molecular Formula

C₁₄H₁₁F₃N₂OS

SMILES

OC1=NC(C2=CC=C(C(F)(F)F)C=C2)=NC3=C1CSCC3

Target & IC50

Tankyrase 1: IC50 = 11 nM
Tankyrase 2: IC50 = 4 nM
Protein Wnt-3a: IC50 = 51 nM
Catenin beta-1: IC50 = 51 nM (human)

Solubility

DMSO: 12 mg/mL (38.42 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
XAV939 is a potent, small molecule inhibitor of tankyrase 1 (TNKS) (IC₅₀ = 11 nM) and tankyrase 2 (IC₅₀ = 4 nM). By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells. At concentrations as low as 0.3 μM, XAV939 inhibits colony formation of APC-deficient colorectal cancer cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol