Protein Inhibitors - GSK-3 Inhibitor IX (CAS: 667463-62-9)

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GSK-3 Inhibitor IX (CAS: 667463-62-9)

Catalog #：EBC51068

GSK-3 Inhibitor IX (CAS: 667463-62-9)

SKU-Pack Size	Availability	Size	Price
EBC51068-1ML	In Stock	1mL(10mM in DMSO)	€128.70
EBC51068-2MG	In Stock	2mg	€63.70
EBC51068-5MG	In Stock	5mg	€102.70
EBC51038-10MG	In Stock	10mg	€141.70
EBC51037-50MG	In Stock	50mg	€518.70

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	Dianost	Phone：+49 (0) 40 65472-053
	Bullenkoppel 11， 23896 Poggensee,	E-mail：ola@olasciences.com
Germany	Germany	Web：www.olasciences.com

Product Information

Synonym(s)

BIO, 6-Bromoindirubin-3'-oxime

Chemical Name

(2'Z,3'E)-6-Bromoindirubin-3'-oxime

Application

GSK-3 Inhibitor IX is a specific inhibitor of GSK-3

CAS Number

667463-62-9

Purity

≥99.0%

Molecular Weight

356.17

Molecular Formula

C₁₆H₁₀BrN₃O₂

SMILES

O/N=C1/C(=C2C(=O)Nc3cc(Br)ccc/23)Nc2ccccc12

Target & IC50

GSK-3α/β: IC50 = 5 nM
Cdk5/p25: IC50 = 83 nM
Cdk2/A: IC50 = 300 nM
Cdk1/B: IC50 = 320 nM
Cdk4/D1: IC50 = 10 μM

Solubility

DMSO: 71 mg/mL (199.34 mM)
Ethanol: 21 mg/mL (58.96 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.8076 ml	14.0382 ml	28.0765 ml
5 mM	0.5615 ml	2.8076 ml	5.6153 ml
10 mM	0.2808 ml	1.4038 ml	2.8077 ml
50 mM	0.0562 ml	0.2808 ml	0.5615 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

GSK-3 Inhibitor IX is a cell-permeable selective irreversible inhibitor of glycogen synthase kinase-3 (GSK-3). This inhibitory effect is reported to activate the Wnt signaling pathway and promote self-renewal in human and mouse cells. BIO is also useful in the differentiation of cardiomyocytes from human embryonic cells and Induced pluripotent stem cells as well as cellular reprogramming of mouse cell lines into iPS cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol