Protein Inhibitors - Brefeldin A (CAS: 20350-15-6)

Brefeldin A (CAS: 20350-15-6)

Catalog #：EBC51070

Brefeldin A (CAS: 20350-15-6)

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Product Information

Synonym(s)

Ascotoxin, Cyanein, Decumbin, Synergisidin

Chemical Name

(1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

Application

Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking

CAS Number

20350-15-6

Purity

≥98.0%

Molecular Weight

280.36

Molecular Formula

C₁₆H₂₄O₄

SMILES

O[C@@H]1C[C@H]2[C@H](O)C=CC(=O)O[C@@H](C)CCCC=C[C@@H]2C1

Target & IC50

B-cell specific antigen receptor-induced NF-kB activation: IC50 = 420 nM

Solubility

DMSO: 14 mg/mL (50 mM)
Ethanol: 2.8 mg/mL (10 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Brefeldin A is a lactone antibiotic originating discovered in fungi capable of inhibiting protein transport from the endolasmic reticulum to the Golgi apparatus. It is reported to act on the guanine nucleotide exchange factor named GBF1 that mediates the formation of transport vesicles and the unfolded protein response can result in apoptosis in some cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol