Protein Inhibitors - CHIR-98014 (CAS: 252935-94-7)

CHIR-98014 (CAS: 252935-94-7)

Catalog #：EBC51075

CHIR-98014 (CAS: 252935-94-7)

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Product Information

Synonym(s)

CHIR 98014, CHIR-98014, CT98014

Chemical Name

N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-Pyridinediamine

Application

CHIR-98014 is a selective and ATP-competitive inhibitor of GSK-3β

CAS Number

252935-94-7

Purity

≥99.0%

Molecular Weight

486.31

Molecular Formula

C₂₀H₁₇Cl₂N₉O₂

SMILES

C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N

Target & IC50

GSK-3 β: IC50 = 0.58 nM
GSK-3 α: IC50 = 0.65 nM

Solubility

DMSO: 8 mg/mL (16.45 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
CHIR-98014 is a selective and ATP-competitive inhibitor of Glycogen Synthase Kinase 3β(GSK-3β) with Ki values of 0.87 nM. In addition, CHIR-98014 displays 500 to greater than 1000-fold selectivity towards GSK3 than other protein kinases such as cdc2 and erk2. The inhibitory effects of CHIR-98014 are similar for both α and β isoforms of GSK-3.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol