Protein Inhibitors - CHIR-99021 (CAS: 252917-06-9)

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CHIR-99021 (CAS: 252917-06-9)

Catalog #：EBC51076

CHIR-99021 (CAS: 252917-06-9)

SKU-Pack Size	Availability	Size	Price
EBC51076-1ML	In Stock	1mL(10mM in DMSO)	￥1190.00
EBC51076-2MG	In Stock	2mg	￥690.00
EBC51076-5MG	In Stock	5mg	￥990.00
EBC51076-10MG	In Stock	10mg	￥1590.00
EBC51076-25MG	In Stock	25mg	￥2890.00

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Product Information

Synonym(s)

GSK-3 Inhibitor XVI

Chemical Name

6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

Application

CHIR-99021 is a GSK-3α/β inhibitor

CAS Number

252917-06-9

Purity

≥99.0%

Molecular Weight

465.34

Molecular Formula

C₂₂H₁₈Cl₂N₈

SMILES

N#CC(C=N1)=CC=C1NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2

Target & IC50

GSK-3α: IC50 = 10 nM
GSK-3β: IC50 = 6.7 nM

Solubility

DMSO: 78 mg/mL (167.62 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.1490 ml	10.7448 ml	21.4897 ml
5 mM	0.4298 ml	2.1490 ml	4.2979 ml
10 mM	0.2149 ml	1.0745 ml	2.1490 ml
50 mM	0.0430 ml	0.2149 ml	0.4298 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
CHIR 99021 is an aminopyrimidine derivate that is a selective and potent inhibitor of glycogen synthase kinase 3 (GSK-3). It is used to maintain human and mouse stem cell lines and, in combination with other reagents, to chemically reprogram somatic cells into stem cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol

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