Protein Agonists, Antagonists and Activators - Dibutyryl-cAMP, sodium salt (CAS: 16980-89-5)

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Dibutyryl-cAMP, sodium salt (CAS: 16980-89-5)

Catalog #：EBC51086

Datasheet

Dibutyryl-cAMP, sodium salt
(CAS: 16980-89-5)

SKU-Pack Size	Availability	Size	Price
EBC51086-1ML	In Stock	1mL(10mM in DMSO)	€63.70
EBC51086-25MG	In Stock	25mg	€63.70
EBC51086-50MG	In Stock	50mg	€102.70
EBC51086-100MG	In Stock	100mg	€128.70
EBC51086-1G	In Stock	1g	€648.70

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Product Information

Synonym(s)

Dibutyryl-cAMP, Bucladesine sodium salt

Chemical Name

sodium (4aR,6S,7R,7aR)-6-(6-butyramido-9H-purin-9-yl)-7-(butyryloxy)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide

Application

Dibutyryl-cAMP, sodium salt is a cell-permable analog of cyclic AMP (cAMP) that stimulates cAMP-dependent protein kinases.

CAS Number

16980-89-5

Purity

≥99.0%

Molecular Weight

491.37

Molecular Formula

C₁₈H₂₃N₅NaO₈P

SMILES

CCCC(=O)NC1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]

Target & IC50

PKA

Solubility

DMSO: 49.1 mg/mL (100 mM) H₂O
: 49.1 mg/mL (100 mM)
Ethanol：49.1 mg/mL (100 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.0351 ml	10.1756 ml	20.3513 ml
5 mM	0.4070 ml	2.0351 ml	4.0703 ml
10 mM	0.2035 ml	1.0176 ml	2.0351 ml
50 mM	0.0407 ml	0.2035 ml	0.4070 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

Dibutyryl-cAMP, sodium salt is an analog of cyclic AMP that stimulates PKA (cAMP-dependent protein kinase). Dibutyryl-cAMP has been shown not to effect cAMP levels, gap junction communication or cumulus expansion in cumulus-oocyte complexes. Research shows that dibutyryl-cAMP can stimulate the activity of Na+, K+-ATPase (Na+,K+-pump), bring about morphological differentiation of astrocytes, and block contraction of vas deferens in rat studies. Additionally, other studies show that Dibutyryl-cAMP can upregulate Nur77 expression through modification of histones during neurite outgrowth in PC-12 cells, and regulate the mRNA levels of Dp71 and dystrophin in rat brain astrocytes.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol