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Location：Home > Biochemicals > Protein Inhibitors
Dorsomorphin (CAS: 866405-64-3)
Catalog #：EBC51090
Dorsomorphin (CAS: 866405-64-3)
  SKU-Pack Size Availability Size Price
EBC51090-1ML In Stock 1mL(10mM in DMSO) ￥890.00
EBC51090-5MG In Stock 5mg ￥690.00
EBC51090-10MG In Stock 10mg ￥990.00
EBC51090-25MG In Stock 25mg ￥1990.00
EBC51090-50MG In Stock 50mg ￥2990.00
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Product Information
Synonym(s) Compound C, AMPK Inhibitor, BML-275
Chemical Name 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine
Application Dorsomorphin is an effective and specific inhibitor of AMPK
CAS Number 866405-64-3
Purity ≥99.0%
Molecular Weight 399.49
Molecular Formula C₂₄H₂₅N₅O
SMILES C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3
Target & IC50 KDR/VEGFR2: IC50 = 25.1 nM
ALK2/BMPR-I: IC50 = 148 nM
AMPK kinase: IC50 = 234.6 nM
Solubility DMSO： 3 mg/mL (7.51 mM)
Ethanol： 2 mg/mL (5.01 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.5032 ml 12.5160 ml 25.0319 ml
5 mM 0.5006 ml 2.5032 ml 5.0064 ml
10 mM 0.2503 ml 1.2516 ml 2.5032 ml
50 mM 0.0501 ml 0.2503 ml 0.5006 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Dorsomorphin is a potent and selective inhibitor of the BMP pathway through the ALK2, ALK3, and ALK6 receptors. It is also a selective and reversible inhibitor of the AMP-activated protein kinase (AMPK). Dorsomorphin is reported to be useful in promoting specific cell differentiation and inducing cancer cell line autophagy. 
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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