Protein Inhibitors - SU 16f (CAS: 251356-45-3)

SU 16f (CAS: 251356-45-3)

Catalog #：EBC51095

SU 16f (CAS: 251356-45-3)

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Product Information

Synonym(s)

SU-16f, PDGFR Tyrosine Kinase Inhibitor VII

Chemical Name

(E)-3-(2,4-dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid

Application

SU 16f is a potent PDGFRβ inhibitor

CAS Number

251356-45-3

Purity

≥98.0%

Molecular Weight

386.44

Molecular Formula

C₂₄H₂₂N₂O₃

SMILES

O=C(O)CCC1=C(C)NC(/C=C2C(NC3=C\2C=CC(C4=CC=CC=C4)=C3)=O)=C1C

Target & IC50

Flk-1: IC50 = 0.14 μM
FGFR1: IC50 = 2.29 μM
PDGFRβ: IC50 = 10 nM

Solubility

Soluble in DMSO (100 mM)

Preparing Stock Solutions

Shipping

Room Temperature

Storage

Room Temperature

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
SU 16f is a selective PDGFRβ inhibitor with an IC50=10nM. In vitro studies demonstrate that SU 16f also inhibits HUVEC and NIH3T3 cell proliferation with an IC50=0.11μM. In addition, SU 16f displays 14 fold selectivity towards PDGFRβ compared to Flk-1 (VEGFR2), 229-fold over Flg (FGFR1) and 10000-fold over EGFR. SU 16f is an inhibitor of Flk-1.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol