Protein Inhibitors - Go 6983 (CAS: 133053-19-7)

Go 6983 (CAS: 133053-19-7)

Catalog #：EBC51102

Go 6983 (CAS: 133053-19-7)

If you want to get a larger packsize, Please contact your local distributor or
email us atinfo@ebiocell.com

Please Select The Country You Are In To Find Your Local Distributor.

	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information

Synonym(s)

Gö 6983, Goe 6983, Gouml 6983, inhibitor

Chemical Name

3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Application

Go 6983 is a PKC inhibitor that selectively inhibits PKC isoenzymes

CAS Number

133053-19-7

Purity

≥98.0%

Molecular Weight

442.50

Molecular Formula

C₂₆H₂₆N₄O₃

SMILES

CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

Target & IC50

PKCα: IC50 = 7 nM
PKCβ: IC50 = 7 nM
PKCγ: IC50 = 6 nM
PKCδ: IC50 = 10 nM
PKCζ: IC50 = 60 nM

Solubility

DMSO: 88 mg/mL (198.87 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Go 6983 is a broad fast-acting inhibitor of various isoforms of protein kinase C. It can be used to inhibit differentiation and maintain the pluripotency of embryonic stem cells and enhance stem cell viability and growth. Go 6983 is also reported to exert cardio protective effects in myocardial ischemia and inhibited intracellular Ca accumulation.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol