Protein Inhibitors - SU 5402 (CAS: 215543-92-3)

SU 5402 (CAS: 215543-92-3)

Catalog #：EBC51106

SU 5402 (CAS: 215543-92-3)

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Product Information

Synonym(s)

SU5402, SU-5402, VEGFR and FGFR inhibitor

Chemical Name

3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

Application

SU 5402 is a FGFR-specific tyrosine kinase inhibitor

CAS Number

215543-92-3

Purity

≥99.0%

Molecular Weight

296.32

Molecular Formula

C₁₇H₁₆N₂O₃

SMILES

CC1=CNC(\\C=C2/C(=O)NC3=CC=CC=C23)=C1CCC(O)=O

Target & IC50

VEGFR2: IC50 = 20 nM
FGFR1: IC50 = 30 nM
PDGFRβ: IC50 = 510 nM

Solubility

DMSO: 59 mg/mL (199.11 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
SU 5402 is a potent and selective fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR) inhibitor. It is reported to exhibit antitumor properties, attenuates the integrin Beta4-induced differentiation of neural stem cells, and inhibits embryonic left-right determination.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol