Protein Inhibitors - IWP-3 (CAS: 687561-60-0)

IWP-3 (CAS: 687561-60-0)

Catalog #：EBC51121

IWP-3 (CAS: 687561-60-0)

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Product Information
Synonym(s)	Inhibitor of Wnt Production-3, IWP3, IWP 3
Chemical Name	2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-acetamide
Application	IWP-3 is an inhibitor of Wnt production
CAS Number	687561-60-0
Purity	≥98.0%
Molecular Weight	484.59
Molecular Formula	C₂₂H₁₇FN₄O₂S₃
SMILES	O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=C(F)C=C5)=O
Target & IC50	Wnt: IC50 = 40 nM
Solubility	DMSO: 2 mg/ml
Shipping	Gel Pack
Storage	Store at -20°C
Research Use	For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
IWP-3 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol