Protein Inhibitors - LY 2157299 (CAS: 700874-72-2)

LY 2157299 (CAS: 700874-72-2)

Catalog #：EBC51136

LY 2157299 (CAS: 700874-72-2)

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Product Information

Synonym(s)

LY 2157299, LY-2157299, Galunisertib

Chemical Name

4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide

Application

LY2157299 is a potent TGF β RI inhibitor

CAS Number

700874-72-2

Purity

≥98.0%

Molecular Weight

369.42

Molecular Formula

C₂₂H₁₉N₅O

SMILES

CC1=CC=CC(=N1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N

Target & IC50

Flk-1: IC50 = 442 nM
TGFβ RI: IC50 = 56 nM

Solubility

DMSO: 74 mg/mL (200.31 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
LY 2157299 is a potent inhibitor of Transforming Growth factor-Beta Receptor I (TGF-BetaR). TGF-Beta1 is involved in the control of cell growth, proliferation, differentiation, and apoptosis. LY2157299 is reported to disrupt Smad-2 phosphorylation in Human Umbilical Vein Endothelial Cells (HUVEC) and inhibit the growth and migration of tumor cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol