Protein Inhibitors - MK-886 sodium salt (CAS: 118427-55-7)

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MK-886 sodium salt (CAS: 118427-55-7)

Catalog #：EBC51140

MK-886 sodium salt
(CAS: 118427-55-7)

SKU-Pack Size	Availability	Size	Price
EBC51140-1MG	In Stock	1mg	￡64.90
EBC51140-5MG	In Stock	5mg	￡108.90
EBC51140-10MG	In Stock	10mg	￡163.90
EBC51140-25MG	In Stock	25mg	￡306.90
EBC51140-50MG	In Stock	50mg	￡493.90

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Product Information

Synonym(s)

MK 886,MK886, L663536

Chemical Name

3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid . Na

Application

MK-886 sodium salt is a potent and selective inhibitor of FLAP and Cox-1

CAS Number

118427-55-7

Purity

≥98.0%

Molecular Weight

494.06

Molecular Formula

C₂₇H₃₃ClNO₂S•Na

SMILES

CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)[O-])CC3=CC=C(C=C3)Cl.[Na+]

Target & IC50

leukotriene: IC50 = 2.5 nM
leukotriene: IC50 = 1.1 μM

Solubility

DMSO: 25 mg/mL (50.6 mM)
Ethanol: 25 mg/mL (50.6 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.0240 ml	10.1202 ml	20.2405 ml
5 mM	0.4048 ml	2.0240 ml	4.0481 ml
10 mM	0.2024 ml	1.0120 ml	2.0241 ml
50 mM	0.0405 ml	0.2024 ml	0.4048 ml

Shipping

Room Temperature

Storage

Room Temperature

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

MK-886 sodium salt, also designated L-663,536, is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP). FLAP is an arachidonic acid binding protein that is critical in the biosynthesis of leukotrienes. Inhibitors of FLAP prevent translocation of 5-lipoxygenase from the cytosol to the membrane and inhibit 5-lipoxygenase (5-LO) activation. MK-886 binds to FLAP with high affinity and prevents the activation of 5-LO, thus inhibiting leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. MK-886 sodium salt is an inhibitor of Cox-1, PGE Synthase and PPARα.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol