IkBα also known as IκBalpha, NFKBIA is a member of the NF-kappa-B inhibitor family, which plays a crucial role in the regulation of the NF-κB signaling pathway, which is vital for controlling immune responses, cell proliferation, and survival. By sequestering NF-κB dimers in the cytoplasm, IκB-α prevents their translocation to the nucleus, thereby inhibiting the expression of target genes involved in inflammation and immune responses. The importance of IκB-α′s function is underscored by involvement in various diseases, including cancer and autoimmune disorders, where dysregulation of NF-κB activity can lead to pathological conditions. Additionally, IκB-α undergoes post-translational modifications, such as phosphorylation, which can influence stability and interaction with NF-κB, further highlighting a critical role in cellular signaling.