CaMKIIδ also known as CaMKIIdelta, CAMK2D belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKIIδa plays a crucial role in various cellular processes, particularly in regulating synaptic plasticity and memory formation in the brain. CaMKIIδ is predominantly located in the postsynaptic density of neurons, where CaMKIIδ is involved in phosphorylating various substrates that modulate synaptic strength and neuronal signaling pathways. Proper functioning of CaMKIIδ is essential for long-term potentiation, a cellular mechanism underlying learning and memory.