Polyclonal Antibodies - Phospho-GSK-3α/β (Tyr279/216) Rabbit Polyclonal Antibody

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Phospho-GSK-3α/β (Tyr279/216) Rabbit Polyclonal Antibody

Catalog #：EAB10231

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB10231-30UL	In Stock	30ul	￡119.90
EAB10231-100UL	In Stock	100ul	￡251.90
EAB10231-200UL	In Stock	200ul	￡405.90

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email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, IF/ICC, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300　 IF/ICC=1:50-300
MW (kDa)	51, 47
Conjugate	Unconjugate
Specificity	Phospho-GSK-3α/β (Tyr279/216) Rabbit Polyclonal Antibody detects endogenous levels of GSK-3α and GSK-3β proteins only when phosphorylated at Tyr279 or Tyr216.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Glycogen synthase kinase 3 alpha/beta; GSK-3; GSK3; GSK-3alpha/beta; GSK3alpha/beta; GSK3α/β; GSK-3α/β; GSK3A/B; GSK3A/GSK3B
Gene Aliases	GSK3A/GSK3B
UniProt ID	P49840, P49841
Entrez Gene ID	2931, 2932

Product Description

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase that plays a crucial role in numerous signaling pathways, particularly those involved in glycogen metabolism and cellular adhesion, and has been linked to the pathogenesis of Alzheimer′s disease. GSK-3 exists in two isoforms, GSK-3α and GSK-3β, which differ in subcellular localization, with GSK-3α primarily found in the cytoplasm and GSK-3β localized in both the cytoplasm and nucleus. This differential localization is significant as GSK-3 may influence specific signaling pathways that each isoform regulates, thereby affecting cellular responses to various stimuli.

Product Image Gallery
Western blot analysis of extracts on Hela cells, using Phospho-GSK-3α/β (Tyr279/216) Rabbit Polyclonal Antibody (EAB10231) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol