P09619

PDGF Receptor β also known as PDGFR beta, PDGFRB is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. PDGF Receptor β plays a crucial role in cell signaling, particularly in the regulation of cell growth, survival, and migration, which are vital processes in tissue repair and development. PDGFR-β is primarily located on the surface of mesenchymal and glial cells, where PDGFR-β mediates the effects of its ligand, PDGF-BB, leading to receptor dimerization and activation of downstream signaling pathways. PDGFR-β′s ability to bind specifically to the B subunit of PDGF is essential for its function, as PDGFR-β triggers a cascade of intracellular events that influence cellular behavior. Dysregulation of PDGFR-β signaling has been implicated in various pathologies, including chronic myelomonocytic leukemia (CMML), highlighting PDGFR-β′s importance as a therapeutic target in cancer treatment.