P02545

Lamin A/C plays a crucial role in maintaining the structural integrity of the nuclear envelope, which is essential for proper cellular function and organization. Lamin A/C is located in the nuclear lamina, a dense fibrillar network inside the nucleus, where Lamin A/C provides mechanical support and regulates important processes such as DNA replication and cell division. The significance of Lamin A/C extends beyond structural support; Lamin A/C is also involved in chromatin organization and gene expression regulation. Disruptions in Lamin A/C function can lead to various diseases, including muscular dystrophies and progeria, highlighting Lamin A/C′s importance in cellular health and longevity. Lamin A is cleaved by the protease Mch2 during apoptosis, while Lamin C, a splice variant of Lamin A, shares a high degree of similarity with Lamin A but differs at the carboxy-terminus, which may influence specific interactions and functions within the cell.