Q02763

Tie2 also known as Tek is a receptor tyrosine kinase that plays a crucial role in angiogenesis and vascular stability, making Tie-2 essential for proper blood vessel formation and maintenance. Tie-2 is primarily expressed in endothelial cells and is involved in mediating the effects of angiopoietins, which are key regulators of blood vessel development and remodeling. The interaction between Tie-2 and its ligands is vital for maintaining endothelial cell integrity and preventing vascular leakage, which is particularly important in pathological conditions such as cancer and inflammatory diseases.