Q8WXE1

ATRIP plays a crucial role in DNA damage response, particularly in activating the ATR (ATM and Rad3-related) signaling pathway, which maintains genomic stability. ATRIP helps activate downstream checkpoint responses that prevent cell cycle progression until damage repair. This function ensures cells don′t replicate damaged DNA, which could lead to mutations and cancer. ATRIP interacts with replication protein A (RPA) complex, facilitating ATR binding to single-stranded DNA, enhancing cellular response to replication stress. Nuclear localization of ATRIP underscores its importance in DNA repair processes, making ATRIP a significant target for cancer biology studies and therapeutic interventions.