Polyclonal Antibodies - Chk2 Rabbit Polyclonal Antibody

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Chk2 Rabbit Polyclonal Antibody

Catalog #：EAB10688

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB10688-30UL	In Stock	30ul	$133.50
EAB10688-100UL	In Stock	100ul	$298.50
EAB10688-200UL	In Stock	200ul	$508.50

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email us at info@ebiocell.com

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	EbioCell	Phone：(540) 808-3925
	Imperial Business Park 4819 Emperor Boulevard,	E-mail：order@ebiocell.com
United States	Suite 408 Durham, NC 27703, USA	Web：www.ebiocell.com

Product Information
Applications	WB, IHC-P, IF, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300　 IF=1:50-300
MW (kDa)	61
Conjugate	Unconjugate
Specificity	Chk2 Rabbit Polyclonal Antibody detects endogenous levels of Chk2 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Checkpoint kinase 2; CDS1; CHK2; LFS2; RAD53; TPDS4; hCds1; HuCds1; PP1425; CHEK2
Gene Aliases	CHEK2
UniProt ID	O96017
Entrez Gene ID	11200

Product Description

Chk2(Checkpoint kinase 2) also known as CHEK2 plays a critical role in the cellular response to DNA damage, functioning as a key regulator in the G2 DNA damage checkpoint. Upon DNA damage, Chk2 is activated and phosphorylates Cdc25C, which inhibits its phosphatase activity, thereby preventing the activation of cyclin-dependent kinases and blocking the progression of mitosis. This mechanism is vital for maintaining genomic stability, as it allows the cell time to repair DNA before division, thus preventing the propagation of damaged DNA. Additionally, Chk2 interacts with various proteins involved in the DNA damage response, including p53, further underscoring its importance in tumor suppression and cellular integrity.

Product Image Gallery
Western blot analysis of extracts on Hela, HCT116, SW480, Jurkat, HEK293 cells, using Chk2 Rabbit Polyclonal Antibody (EAB10688) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol