FLT3 also known as CD135, STK1, FLK2 is a class III receptor tyrosine kinase that regulates hematopoiesis. FLT3 plays a crucial role in hematopoiesis as FLT3 is involved in the regulation of hematopoietic stem and progenitor cell proliferation and differentiation. FLT3 is primarily expressed in CD34+ cells, which are essential for the formation of blood cells, and FLT3 signaling is vital for maintaining the balance between self-renewal and differentiation of these stem cells. The interaction of FLT3 with its ligands can lead to the activation of downstream signaling pathways that promote cell survival and proliferation, making FLT3 a significant target for therapeutic interventions in hematological malignancies.